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  • Arrays found ck19 the most sensitive for papillary carcinoma and hbme-1 the most specific, with the proposal that the two should be used in a complementary way: if all four markers are used, strong expression of two or more markers (particularly hbme-1) strongly supports papillary carcinoma; negativity for three or four markers strongly favours follicular adenoma5. buy cheap viagra viagra for sale cheap viagra generic best price buy cheap viagra viagra online viagra without a doctor prescription buy canadian viagra online today buy viagra online cheap generic viagra viagra without a doctor prescription However, none of the combinations in this study was statistically superior to hbme-1 alone.     classical papillary carcinoma follicular variant of papillary carcinoma of thyroid papillary microcarcinoma follicular adenoma follicular carcinoma hurtle cell carcinoma anaplastic carcinoma papillary carcinoma vs follicular adenoma     specificity sensitivity     hbme-1 (membrane staining5: only basolateral membranous staining is considered positive6) 43/495, 19/206, 57/677 25/295, 9/106 21/216 2/495, 0/66, 2/217 3/67 1/87 0/47 96% (vs follicular adenoma) 5, 96% (vs follicular adenoma and non-neoplastic conditions)%6 87% (vs follicular adenoma) 5, 93% (vs follicular adenoma and non-neoplastic conditions)%6     ck19 (cytoplasmic staining5,6) 49/495, 20/206, 48/677 26/295, 10/106 21/216 7/495, 5/66 3/67 4/87 1/47 86% (vs follicular adenoma) 5, 100% (vs follicular adenoma and non-neoplastic conditions) 6 96% (vs follicular adenoma) 5, 32% (vs follicular adenoma and non-neoplastic conditions) 6     cited1 (membrane staining5) 44/495, 19/196, 58/677 24/295, 7/76   8/495, 6/66, 2/217 3/67 2/87 0/47 84% (vs follicular adenoma) 5 87% (vs follicular adenoma) 5     galectin-3+ (cytoplasmic and some nuclear staining5) 47/495, 63/677 26/295   9/495, 2/217 4/67 7/87 4/47 82% (vs follicular adenoma) 5 94% (vs follicular adenoma) 5     hbme-1+ & ck19+ & galectin-3+ 42/495 23/295   0/495       100% (vs follicular adenoma) 5 83% (vs follicular adenoma) 5     fn1 (staining mostly weak, focal and cytoplasmic: background staining makes interpretation difficult) 20/206, 61/677 7/106 8/216 2/66, 1/217 3/67 6/87 4/47 96% (vs follicular adenoma and non-neoplastic conditions) 6 93% (vs follicular adenoma and non-neoplastic conditions) 6     hbme-1+ & ck19+ & fn1 35/516                 sftpb (mostly weak and focal) 5/196 0/76   0/66               ki-67 (cytoplasmic) 18/196 0/76   0/66               calretinin 3/106                     p16 10/106                     cst6 8/106                     eps8 10/106                                             galectin-3 shows the most intense staining in the advancing tongues of minimally invasive follicular carcinoma 1,2,4 and may be helpful in differentiating a follicular adenoma from a minimally invasive carcinoma. Some consider the predictive value limited:   accuracy of galectin-3 in differentiating.
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